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Agno supports audio as input to agents and teams. Take a look at the compatibility matrix to see which models support audio as input. Let’s create an agent that can understand audio input.
audio_agent.py
import base64

import requests
from agno.agent import Agent, RunOutput  # noqa
from agno.media import Audio
from agno.models.openai import OpenAIResponses

# Fetch the audio file and convert it to a base64 encoded string
url = "https://openaiassets.blob.core.windows.net/$web/API/docs/audio/alloy.wav"
response = requests.get(url)
response.raise_for_status()
wav_data = response.content

agent = Agent(
    model=OpenAIResponses(id="gpt-5.2-audio-preview", modalities=["text"]),
    markdown=True,
)
agent.print_response(
    "What is in this audio?", audio=[Audio(content=wav_data, format="wav")]
)